The flux or the amount of glucose that is broken down in the…
The flux or the amount of glucose that is broken down in the glycolysis pathway is primarily controlled by the regulation of the enzyme phosphofructokinase I (PFK I). This enzyme is strongly activated by AMP and inhibited by citrate. A) Briefly explain why these two compounds are good choices for regulation of PFK I. (2 pts.) AMP: Citrate: B) The enzyme phosphofructokinase II (PFK-2) coverts fructose-6-phosphate to fructose-2,6-bisphosphate, which is a potent activator of phosphofructokinase I (PFK-1). The activity of PFK-2 is regulated by PKA phosphorylation. Is the kinase activity of PFK-2 activated or inhibited in the liver in response to epinephrine? (1 pt.)