The following is correct concerning human immunodeficiency v…
The following is correct concerning human immunodeficiency virus (HIV) resistance to protease inhibitors: (1)1. High-level resistance occurs to the reverse transcriptase enzyme.2. It occurs as an accumulation of stepwise mutations of the protease gene.3. It occurs to prevent allosteric inhibition of the reverse transcriptase enzyme.4. Resistance occurs as four specific substitutions of the integrase gene.5. A single-point mutation occurs within the integrase gene.