The imidazole side chain of the hemoglobin beta chain residu…
The imidazole side chain of the hemoglobin beta chain residue His-β146 has a pKa of 7.9 when in the T state (shown below). Determine how its ionization state will change and how it will affect its interaction with the Asp-β94 side chain as the pH shifts from 7.2 in the muscle to 7.4 in the lungs. Enter Increase, Not change, or Decrease. 1b86.png Prompt Response His-β146 imidazole ionization state will His-β146 imidazole interaction with Asp-β94 side chain will