The mechanism of action of poison hemlock alkaloids are two-…
The mechanism of action of poison hemlock alkaloids are two-fold. They are antagonists of the nicotinic type of acetylcholine receptors. The most serious effect are at the _________________ where they act as non-depolarizing blockers similar to curares. Death, when it occurs, is usually due to respiratory failure. They also act on the __________ ganglia (which are present in both sympathetic and parasympathetic), due to which they produce biphasic nicotinic like effects (due to effects on both sympathetic and parasympathetic systems), including salivation, mydriasis (dilation of the pupil of the eye), tachycardia followed by bradycardia. And, sometimes, rhabdomyolysis (destruction of skeletal muscle) and acute tubular necrosis occurs (due to release of myoglobins from muscle causing myoglobinuria). Choose the best combination of terms to fill in the blanks.