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The аnnоuncement оf the CRISPR-gene edited bаbies hаs prоmpted many prominent scientists and bioethicists to propose strict new guidelines for human germline editing. One recommendation is that heritable human genome editing should be limited to serious monogenic diseases that causes severe morbidity or premature death. [true1] A second recommendation is that if a couple is only expected to have 25% (of fewer) unaffected embryos, they should first attempt IVF with pre-implantation genetic testing before considering genome editing. [true2]