Upload an image of your drawings. One of the intermediat…
Upload an image of your drawings. One of the intermediates in the biosynthesis of epinephrine is the amino acid L-dopa, which has two phenolic OH groups at the 3 and 4 positions of the benzene ring of Phe. Following the PLP mediated decarboxylation of L-dopa, the side chain alkyl group is hydroxylated to form the hormone norepinephrine. The final step in the biosynthesis of epinephrine is N-methylation of norepinephrine to form epinephrine by SAMe (S-adenosy methionine). Outline the series of reactions that would take a carbon atom from either Ser or Gly and deliver it as a methyl group to norepinephrine to form epinephrine. Show all necessary cofactors. You may use names, structures, or acceptable abbreviations. (4 pts.) Following the transfer of a methyl group, SAMe is converted to homocysteine. High levels of homocysteine in the blood have been correlated with coronary heart disease, stroke, atherosclerosis, neural tube defects, and dementia in the elderly. Homocysteine can react with Ser with the loss of water to form cystathionine. Cystathionine is cleaved to form Cys and α-ketobutyrate in a PLP dependent reaction. Show the series of reactions that converts