What is the mechanism of action of lumefantrine? …
What is the mechanism of action of lumefantrine? 1. It inhibits the detoxification of the heme in the erythrocyte2. Its metabolites produce reactive oxygen species which are fatal to the malaria parasite3. It inhibits plasmodial dihydrofolate reductase required for the synthesis of tetrahydrofolate4. Inhibits nucleic acid synthesis by oxidizing amoebic DNA5. Inhibits plasmodial protein synthesis by binding to 30S ribosomal subunits