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Which of the following hormones is secreted when serum gluco…
Which of the following hormones is secreted when serum glucose levels rise?
Which of the following hormones is secreted when serum gluco…
Questions
Which оf the fоllоwing hormones is secreted when serum glucose levels rise?
Tо elucidаte the rоle оf аnti-Mülleriаn hormone (AMH) in follicular recruitment, its regulatory mechanisms, and its potential applications in treating reproductive diseases and preserving fertility in women undergoing cancer treatments. Objective 1: To determine the mechanisms governing AMH release and its role in preventing primordial follicle activation. Hypothesis 1: AMH expression is stimulated by oocyte-derived growth factors BMP15 and GDF9, which modulate granulosa cell proliferation and differentiation. AMH reduces follicular sensitivity to FSH by downregulating FSH receptor expression. Objective 2: To investigate the role of AMH in the pathogenesis of reproductive diseases such as PCOS and related cancers. Hypothesis 2: Elevated AMH levels contribute to decreased antral follicle count and ovulatory dysfunction, leading to estrogen deficiency and luteal insufficiency, which are key factors in PCOS and certain cancers. Objective 3: To explore the use of supplemental AMH for fertility preservation in women undergoing chemotherapy. Hypothesis 3: Supplemental AMH will arrest follicular development, maintaining quiescent follicles during chemotherapy, and allowing resumption of regular cycles post-treatment, thus preserving fertility. References: Convissar, S., et al. (2017). Regulation of AMH by Oocyte-Specific Growth Factors in Human Cumulus Cells. Reproduction, 154(6), 745–753. Rudnicka, E., et al. (2021). Anti-Müllerian Hormone in Pathogenesis and Treatment of PCOS. International Journal of Molecular Sciences, 22(22), 12507.