Which of the following statements about epigenetic inheritan…
Which of the following statements about epigenetic inheritance are true? Select true or false for each statement. Imprinting occurs when males and females downregulate unique sets of genes by promoter methylation. Methylation resulting from imprinting is erased and reset in the germ line each generation. Some methylation events have been shown to demonstrate significant heritability. Following DNA replication, hemimethylated DNA is targeted by DNA methyltransferase 1 (DNMT1) to restore methylation patterns to the newly synthesized strand. A highly condensed chromatin state (heterochromatin) can “spread” on a chromosome, causing descendant cells to sometimes exhibit phenotypic differences because one or more genes are no longer expressed as strongly.