A 24-year-old male presents to his primary care physician fo…
A 24-year-old male presents to his primary care physician for evaluation of recurrent fever, night sweats, and weight loss. The patient reports that he has been experiencing these symptoms for the past several weeks. After a complete physical exam and a series of laboratory and diagnostic tests, the patient undergoes an excisional lymph node biopsy (see image). The pathology report states that Reed-Sternberg cells are present. Staging evaluation determines that the patient has Stage IIB disease. Which of the following statements describes Stage IIB disease?