B Cell Responses (Moser) Vaccines against Streptococcus pneu…
B Cell Responses (Moser) Vaccines against Streptococcus pneumoniae elicit antibody responses against capsular polysaccharides on the outer surface of the bacteria. Protein conjugate vaccines (PCVs) are more effective than vaccines that only contain the capsular polysaccharides because PCVs elicit T-dependent responses. (A) What type of B cell response would be elicited by vaccines that only contain the capsular polysaccharides? (1 point) (B) Which molecule of the PCV recruits T cell help? (2 points) (C) List three features of T-dependent (TD) B cell responses that would provide better protection than T-independent (TI) responses. (3 points) (D) In cognate interactions, B cells and CD4 T cells recognize epitopes that are physically linked. Briefly describe where and how these interactions occur. Name key surface receptors on both the B cell and the T cell. (3 points) (E) What is a difference between epitopes recognized by B cells vs. T cells? (1 point)