Which conclusion best explains how silencing is maintained at these loci despite the loss of H3K27me3?

Which of the following can define the topologically isolated associated domains (TADs)?      

Nancy is investigating a developmentally regulated gene silenced in embryonic stem cells (ESCs) but rapidly activated upon differentiation. She hypothesizes the gene is in a bivalent chromatin state and designs a ChIP-seq experiment to test this. To confirm bivalency, which cell line and combination of ChIP-seq parameters should Nancy use?

Some ads portray individuals experiencing significant financial or social success while consuming a product. For instance, advertisements featuring cars or alcohol products often showcase attractive individuals dressed in upscale attire, surrounded by an entourage, and enjoying luxurious settings. These ads are designed to appeal to:  

Which of the following is has the catalytic activity to add m6A modification to mRNA?    

How are chromosomal territories arranged within the nucleus?   

Extended Answer Question: Answer the following in approximately one paragraph (3-5 well-developed sentences).  Your notes and the textbook may be accessed during the answering of this question but our class discussions may not.  Responses will be graded on the accuracy of chemistry terminology used and the quality and completeness of the explanation, including how well ideas are connected and supported. Is fire matter?    

BONUS QUESTION 2 (1/2 Point): According to your classmate’s case study, norepinephrine (Levophed®) increases cardiac output by increasing contractility and:

A patient who has been taking a benzodiazepine as a sleep aid for several months wishes to stop taking the medication. Why should the nurse recommend gradual tapering?

A patient is prescribed a loop diuretic. Which electrolyte is the priority for the nurse to monitor?