A 20-week pregnant patient presents for her routine ultrasou…

A 20-week pregnant patient presents for her routine ultrasound appointment. Imaging reveals oligohydramnios and complete absence of both fetal kidneys. Further evaluation demonstrates characteristic facial findings, including wide set eyes, parrot-beak nose, low-set ears, and receding chin. Which congenital anomaly is most consistent with these findings?

A 67 year old patient endorses fatigue, abdominal discomfort…

A 67 year old patient endorses fatigue, abdominal discomfort, and “intense itching” after warm showers. Laboratory studies reveal elevated red blood cell, white blood cell, and platelet counts, in addition to splenomegaly on exam. What diagnosis best explains these findings?