In Barnard et al. (2016) researchers developed a predictive…
In Barnard et al. (2016) researchers developed a predictive model that was capable of assigning 7 of 10 individuals to a clinical diagnosis (acne or healthy) based on identified biomarkers. Of those 7 individuals 6 were assigned correctly. Why could the model not assign all individuals to a clinical diagnosis? Think broadly about the microbiome, not specifically about the methods of this paper. For full credit be sure to address the following. Identify the bacterial species most commonly associated with acnes. (2 words maximum) Name one virulence factor associated disease (does not have to be specific to the organism you named in A. (2 words maximum) Define contextual symbiosis/pathogenicity. (1 sentence maximum) List three potential contributors to disease other than the microbiota. (1 sentence maximum) Explain how your answers to B, C and D can lead to undiagnosed/misdiagnosed individuals using the predictive model developed in the paper. (3 sentences maximum) Barnard (2016) The balance of metagenomic elements shapes the skin microbiome in acne and health. Nature Scientific Reports. 6:39491.