Mina is a 58-year-old woman is diagnosed with invasive ducta…
Mina is a 58-year-old woman is diagnosed with invasive ductal carcinoma of the breast. Imaging identifies a 3.5-cm primary tumor, and biopsy reveals cancer cells in two axillary lymph nodes. Bone scans demonstrate metastatic lesions in the femur. The oncology team uses staging information to guide treatment and discuss prognosis. Which finding has the greatest impact on determining that this patient has advanced disease?