T Cell Signaling (Brusko) (A) Briefly describe the receptor…
T Cell Signaling (Brusko) (A) Briefly describe the receptor complexes involved Signal 1 and name the intracellular signaling motif present in T cells. (2 points) (B) Briefly describe the receptor and ligand in Signal 2, and name a downstream transcription factor associated with this signal. (2 points) (C) CAR-T cells combine the antigen recognition capacity of a B cell with the internal signaling machinery of a T cell, but their signaling is more limited due in part to a more disorganized immunological synapse, a.k.a. supramolecular activation cluster or SMAC. Briefly describe the two parts of the SMAC and a molecule present within each. (2 points)