Use the following scenario to answer questions #20-#22 Clini…
Use the following scenario to answer questions #20-#22 Clinical Case Scenario: A female carrier of the McLeod phenotype is evaluated for transfusion compatibility. Her red cell population shows mixed Kell antigen expression, with some cells expressing normal Kell antigens and others showing weak Kell expression with acanthocytosis. Explain the molecular basis of lyonization (X-chromosome inactivation) and how it leads to dual Kell antigen populations in female carriers of the McLeod phenotype.